Effects of rhCTLA4Ig on human T lymphocyte in vitro / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12): 165-168, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-857453
ABSTRACT
AIM:
To study the effect of rhCT-LAIg on human T lymphocytes.METHODS:
Primary mixed lymphocyte reaction (MLR), secondary MLR and cytotoxicity assay were used.RESULTS:
CTLA4Ig significantly inhibited primary MLR(P<0.05) and the maximal inhibition was achieved at 72 h of incubation with CTLA4Ig. Secondary MLR experiment showed cells primed in the presence of CT-LA4Ig had a specific hyporesponsiveness when challenged with PBMC from the original donor, yet responded normally to PBMC from the third party donor.CONCLUSIONS:
CTLA4Ig can inhibit T cell proliferation and induce T cell anergy in vitro by blocking B7/CD28 co-stimulatory pathway.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmacological Bulletin
Year:
2002
Type:
Article
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