Effects of polysaccharides from cryptoporus volvatus(peck) schear on leukotrienes generation in guinea pig lung / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12): 169-172, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-857454
ABSTRACT
AIM:
To study the effects of polysaccharides of ferment cultured cryptoporus volvatus (CVPS) on release of leukotrienes from guinea pig lung and Schultz - Dale reaction.METHODS:
The bioassay method and reversed phase high-performance liquid chromatography (RP-HPLC) were used to analyze SRS-A or LTD4 from sensitized or normal guinea pig, after challenged with antigen or A23187 respectively. The antiallergic effects of CVPS were evaluated with Schultz-Dale reaction.RESULTS:
The release of SRS-A or LTD4 from sensitized or normal guinea pigs were greatly reduced by CVPS after antigen or A23187 challenge. The CVPS could also inhibit the Schultz-Dale reaction of sensitized guinea pig (IC50 = 0.49 g·L-1).CONCLUSION:
The effects of CVPS involved in inhibiting release of leukotrienes from lung and antiallergy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmacological Bulletin
Year:
2002
Type:
Article
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