Experimental study of the anti-atherogenesis effects of sodium ferulate in hyperlipidemia rabbit and its mechanisms / 中国药理学通报

ABSTRACT

AIM: To study the anti-atherogenesis action of sodium ferulate and its mechanisms. METHODS: Atherosclerotic rabbit models were duplicated by feeding high lipid forage and ECV304 were cultured with the hyperlipidemic serum. The atherosclerotic plaque area was measured. Scanning electron microscope, spectrophotometer and immunocytochemical methods were used to detected the microstructures of endothelial cell, the content of NO in suspension and the expressions of TGFβ1, bFGF on the cell surfaces. RESULTS: Sodium ferulate could decrease the plaque area, lessen the damnification of endothelial cell induced by HLS, enhance the expression of TGFβ1 and the release of NO from ECs, and reduce the expressions of bFGF in ECs, significantly. CONCLUSION: Sodium ferulate can decrease the atherosclerotic plaque area induced by hypercholesterol, which may be relate to the expression change of cytokines.