Application of nano-drug delivery system in comprehensive targeted therapy for triple-negative breast cancer / 中国药理学与毒理学杂志

ABSTRACT

The treatment of triple-negative breast cancer with highly malignant tumors is limited by the formation of drug-resistant clones of cancer cells and the severe toxicity of conventional chemother- A peutic drugs to normal tissue. Recent studies have shown that in the comprehensive targeted therapy of triple-negative breast cancer not only nano-drug delivery systems, with their unique physical and chemical properties of nanomaterials, can load chemotherapeutic drugs, active gene fragments and immunopotentiator, but also attenuate the effects of chemotherapeutic drugs, inhibit gene proliferation and stimulate the immune system by means of photothermal ablation. So that cancer cells are inhibited and killed. The nano-delivery system has changed the pharmacokinetic characteristics of conventional chemotherapeutic drugs and significantly reduced adverse drug reactions. This article reviews the progress in nano-delivery systems in the comprehensive targeted therapy of triple-negative breast cancer.