Research Advances on Non-Clinical Evaluation in Vitro of Drug-Induced Arrhythmias / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1053-1059, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-857651
ABSTRACT
Drug-induced arrhythmia is one of the main causes of failure in drug development, and it is also a major cause of drug withdrawal, therefore, accurate prediction of drug-induced arrhythmia in the non-clinical research stage is the best way to reduce cost. Literature was retrieved by formally searching PubMed, Metstr, CNKI and Baidu Scholar, 1 479 published articles were found through search method, 63 full-text articles were included. After reviewed the relevant literatures, the advantages and disadvantages of the different experimental cells and the related evaluation methods are assessed, in order to provide reference for toxicity evaluation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2020
Type:
Article
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