Effect of Phospholipid Composition on Intradermal Delivery of Fluorescent Modified Cyclodextrin Liposomes / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1094-1097, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-857657
ABSTRACT
OBJECTIVE:
To compare the intradermal delivery effects of composite phospholipid liposomes composed of different proportions of soy phospholipids (SPC) and hydrogenated soy phospholipids (HSPC) on the fluorescent modified hydroxypropyl-β-cyclodextrin(HP-β-CD), and to optimize the phospholipid composition with the best skin retention.METHODS:
The fluorescent probe, fluorescein isothiocyanate (FITC), was combined with HP-β-CD to prepare fluorescent modified cyclodextrin FITC-HP-β-CD. FITC-HP-β-CD was encapsulated in different composite phospholipid liposomes. The amount of the permeation in the receiving solution and skin retention of the cyclodextrin after 10 h were determined in the in vitro intradermal delivery experiment.RESULTS:
The order of cyclodextrin permeation of liposomes in the receiving solution was SPC > S/H (31) > S/H (11) > S/H (13) > HSPC >FITC-HP-β-CD, while the order of cyclodextrin intradermal retention was S/H (11) > S/H (13) > HSPC > S/H (31) > SPC > FITC-HP-β-CD.CONCLUSION:
Using SPC to prepare liposomes is more beneficial to promote the permeation of FITC-HP-β-CD into the skin than HSPC, but the addition of HSPC can increase the skin retention of FITC-HP-β-CD. The S/H(11) liposomes have the better intradermal delivery effect on the fluorescent modified cyclodextrin, of which the skin retention effect is the best.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2020
Type:
Article
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