Optimization of Extraction Process of Thymol and Carvacrol in Origanum vulgare by Box-Behnken Design-Response Surface Methodology / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 883-888, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-857681
ABSTRACT
OBJECTIVE:
To optimize the extraction process of thymol and carvacrol in Origanum vulgare by Box-Behnken design-response surface methodology.METHODS:
On the basis of single factor experiment, taking the sum of extraction rates of thymol and carvicol as the evaluation index, Box-Behnken design was used to investigate the effects of ethanol concentration, liquid-solid ratio and medicinal powder on the extraction rate.RESULTS:
The optimal extraction parameters were as follows ethanol concentration was 80%, liquid to solid ratio was 13∶1 (mL/g), medicinal powder passing through 40 meshes was used, and the highest extraction rate was 694.80 μg•g-1, with a small deviation from the predicted value.CONCLUSION:
The optimal extraction method is simple, with low cost and good predictivity, and it can provide experimental basis for further large-scale production of thymol and carvacrol in Origanum vulgare.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2020
Type:
Article
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