The Distribution of Angiotensin-Converting Enzyme 2 (ACE2) and the Intervention Strategies Targeting the Binding Process of SARS-CoV-2 and ACE2 / 中国药学杂志

ABSTRACT

SARS-CoV-2, which is similar to SARS-CoV, can bind to human cell surface receptor ACE2 through its S-protein, sequentially infecting human cells such as respiratory epithelial cells or corneal and conjunctival tissues, thereby invading the human body. Recent studies have shown that organs with high expression levels of ACE2 protein, such as kidneys and lungs, are more vulnerable to virus damage. Therefore, lots of efforts have been devoted to the development of drugs targeting the combination of SARS-CoV-2 and ACE2. This paper reviewed the most recently published literatures that related to ACE2 and coronavirus infection, with an emphasis on ACE2, especially its distribution in vivo and organ damages of the patients with SARS-CoV-2 infection, as well as recent progress of drug development targeting the binding process of SARS-CoV-2 and ACE2. This paper aimed to shed some light on clinically fight against SARS-CoV-2 infection.