Quality Comparison of Jinyinhua Formula Granules from Different Enterprises Using HPLC Fingerprint / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 631-636, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-857732
ABSTRACT
OBJECTIVE:
To establish the HPLC fingerprint of Jinyinhua formula granules (JYHFG), and compare the qualities of the products from nine enterprises by chemical metrology analysis.METHODS:
HPLC was used to establish fingerprint at 254 nm. Twenty-nine batches of products from nine enterprises were determined, and the quality of JYHFG of different batches was evaluated through similarity evaluation, clustering analysis (HCA) and principal component analysis (PCA).RESULTS:
Seventeen common peaks were confirmed in the HPLC fingerprint of 29 batches of JYHFG, and 10 of them were identified. The similarity of JYHFG was 0.84-0.99, and the samples could be grouped into one category according to enterprise, among which the characteristic peak of chlorogenic acid had the greatest influence on the fingerprint.CONCLUSION:
The establishment of HPLC fingerprint and the identification of chemical pattern provide a more comprehensive reference for the quality control of JYHFG. It provides a reliable method for scientific evaluation and effective quality control.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2020
Type:
Article
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