Establishment of Animal Models for Prediction of Therapeutic Efficacy of Molecularly Targeted Agents on Advanced Hepatocellular Carcinoma / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 527-533, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-857742
ABSTRACT
OBJECTIVE:
To establish a pharmacodynamics testing and predicting model for molecular targeted therapy of advanced hepatocellular carcinoma (HCC).METHODS:
MHCC97-H (a highly aggressive HCC cell line) cells were cultured to establish ①a subcutaneous tumor model in nude mice, ②an in situ HCC tissue seeding model, ③a hepatic portal vein injection of HCC cell model. Nude mice were intragastric admistrated with 2 mg•kg-1 of sorafenib, apatinib or anlotinib per two days. The antitumor effect of sorafenib, apatinib and anlotinib was examined.RESULTS:
Sorafenib, apatinib and anlotinib could significantly inhibit the growth of HCC cells in different models, and the effect of apatinib and anlotinib was better than that of sorafenib.CONCLUSION:
By establishing tumor models of HCC in nude mice, this work provides a strategy to examine the potential antitumor activation of agents for advanced HCC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2020
Type:
Article
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