The investigation of key factors influencing the extraction process of chuanxiong oil by steam distillation / 中国药学杂志

ABSTRACT

OBJECTIVE: To investigate the key process parameters that affect the extraction of essential oil from Ligusticum chuanxiong by steam distillation. METHODS: Volatile oil and emulsified aromatic water are the products of the extraction process of volatile oil. The nature of volatile oil will directly affect the formation of emulsified aromatic water. The influence of extraction temperature, the ratio of liquid to medicine, medicinal material granularity process parameters on the stability of the emulsified fragrance water and the yield of volatile oil were analyzed, furtherly the corresponding extraction process control model of volatile oil was established to reveal the key technology and parameter during the process of volatile oil extraction and separation. RESULTS: The relative viscosity, relative density, surface tension and contact angle of Ligusticum chuanxiong oil decreased gradually with the increase of temperature, while the interfacial tension increased with the increase of temperature. The liner model of aromatic water TSI and process parameters was TSI = 0. 877 + 0. 230 × extraction temperature - 0. 024 × comminution particle size + 0. 010 × liquid ratio + 0. 292 × condensation temperature + 0. 776 × collection temperature. The liner model of the physicochemical properties of TSI and volatile oil was TSI = 0. 877 - 0. 170 × density + 0. 098 × viscosity - 0. 301 × surface tension + 0. 695 × interfacial tension - 0. 060 × contact angle. The liner model of volatile oil yield and process parameters was that yield = 5. 065 + 0. 258 × extraction temperature + 0. 127 × particle size + 0. 016 × liquid ratio + 0. 264 × condensation temperature + 0. 264 × collection temperature + 0. 502 × TSI. The liner model with the physicochemical properties of volatile oil was the yield = 5. 065 - 0. 196 × density - 0. 167 × viscosity - 0. 201 × surface tension + 0. 153 × interfacial tension - 0. 065 × contact angle. CONCLUSION: TSI and yield of aromatic water of Ligusti-cum chuanxiong are directly proportional to the extraction temperature and comminution particle size of medicinal materials. The yield of volatile oil shows a significant positive correlation with the TSI value, which can reflect the yield of volatile oil and is a specific index that can evaluate the process parameters objectively.