Correlation between the area of cerebral infarction and structural topological index for treatment of cerebral infarction drugs / 中国药学杂志

ABSTRACT

OBJECTIVE: To study the relationship between the structural topological index and the area of cerebral infarction, and to explore the correlation between drugs with different molecular connectivity indices and their therapeutic effect. METHODS: Seventy-eight male SD rats (SPF grade) were randomly divided into four groupsdrug group, model blank group, normal group and sham operation group, six rats in each group and to establish cerebral ischemia-reperfusion model. The next day, according to the five half-lives different molecular connectivity index of drugs or distilled water were given, so that blood drug concentration to reach a steady state, after the fifth half-life of drugs for anesthesia, and take out the rat′s brain after staining, fixed treatment. After photographing, the infarct area of rats was calculated by Image-Pro Plus 6 software. By t test and nonlinear regression correlation analysis using IBM SPSS Statistics 24 software the results were analyzed. RESULTS: In the drug group, the average area of cerebral infarction was 21.22%; in the model blank group, 37.23%; the ratio of reduced area to model area was 42.99%, P<0.05. There was significant difference between the two groups. In the piracetam group, 88.111 3% of the cerebral ischemia area was reduced, and the molecular connectivity index of the concentration in vivo was 190.72, 109.66, 74.91, which was significantly different from other common drugs (P<0.05). Nonlinear regression analysis showed that infarct size was correlated with molecular connectivity index, and the correlation coefficient of first order molecular connectivity index was the highest. CONCLUSION: Four groups of drugs have impaired effect on the treatment of cerebral infarction, and the molecular connectivity index of drugs has a significant correlation with the efficacy of drugs.