Characterization of Physicochemical Properties of HPMC from Different Manufacturers and Their Effect on Sustained Release / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1018-1023, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-857993
ABSTRACT
OBJECTIVE:
To investigate the physicochemical properties of hydroxypropyl methylcellulose(HPMC)produced by different manufacturers, and to establish a link between the physicochemical properties of HPMC and its sustained release effect, which can provides a theoretical basis for further rational application.METHODS:
The physicochemical properties of HPMC collected from different manufacturers, such as particle size distribution, bulk density, physical form, crystallinity and degree of substitution were characterized by laser particle size analyzer, bulk density measuring device, scanning electron microscope, X-ray diffractometer and gas chromatography, respectively. Then, the HPMC from different manufacturers were pressed into sustained release tablets, and the sustained release effect was compared by the dissolution curve.RESULTS:
The physicochemical properties of HPMC produced by different factories are different, which are manifested in different particle sizes,different bulk densities, different physical shapes, whether there are differences in crystallization peaks and the content of hydroxypropoxy groups, and the different physicochemical properties directly lead to the difference of sustained release effects.CONCLUSION:
The study of physicochemical properties of HPMC can better control its quality and use it more widely.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2019
Type:
Article
Similar
MEDLINE
...
LILACS
LIS