MicroRNAs Regulate Vascular Smooth Muscle Cell Apoptosis and Cardiovascular Disease / 中国药学杂志

ABSTRACT

microRNAs are non-coding microRNAs composed of 18-22 nucleotides, which play an important role in many aspects such as homeostasis regulation and disease development. They have been confirmed to be involved in the pathogenesis of cardiovascular diseases, including atherosclerosis, myocardial infarction, hypertension, and stent stenosis. miRNAs are stable in the blood circulation, which are regulate the proliferation, differentiation, migration, and apoptosis of vascular smooth muscle cells. Apoptosis has special physiological and pathological significance for cardiovascular diseases, so it may be a new hot spot for the diagnosis and treatment of cardiovascular diseases. This article aims to review the association and clinical application of miRNAs in regulating vascular smooth muscle cell apoptosis and cardiovascular disease. It provides a theoretical basis for the research network of miRNAs regulating the function of vascular smooth muscle cells which involved in cardiovascular disease.