Absorption Study of Allicin in Different Intestinal Segments in Rats by Ussing Chamber System / 中国药学杂志

ABSTRACT

OBJECTIVE: To study the absorption characteristics of allicin in rat intestinal tract.METHODS: An HPLC method was established to determine the content of allicin in rat entericus, and Ussing chamber system was used to investigate the absorption characteristics of garlic spicy element of different concentrations in the duodenum, jejunum, ileum and colon of rats. RESULTS: An HPLC method was established to determine the content of allicin in rat intestinal liquid.The absorption rate constants of allicin in various intestinal segments of rats in the experimental concentration range increased with the increase of allicin concentration.Allicin showed linear absorption in different intestinal segments of rats, with regression correlation coefficients of greater than 0.96, indicating zero order absorption. CONCLUSION: Allicin has different absorption characteristics in different intestinal segments of rats and can be absorbed as prototype.