The Research of Hyaluronic Acid Functionalized Mesoporous Silica Nanoparticles MCM-41 Loading Paclitaxel for SMMC-7721 Liver Cancer Cells / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 110-116, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-858095
ABSTRACT
OBJECTIVE:
To establish a drug delivery system based on hyaluronic acid functionalized mesoporous silica nanoparticles MCM-41 loaded with paclitaxel (HA-MCM-41-PTX). The physical and chemical properties, in vitro drug release and the antitumor effect were investigated.METHODS:
The morphological structure and particle size of MCM-41 were observed by TEM. The drug delivery system was characterized by PXRD and FTIR. The in vitro release experiments was carried out to investigate the dissolution rate of HA-MCM-41-PTX. The in vitro cells experiment was carried out to explore the mechanism of HA-MCM-41-PTX on cells.RESULTS:
The drug loading capacity of HA-MCM-41-PTX was 28.75%. The in vitro drug release experiments showed that HA-MCM-41-PTX exhibited controlled release with a cumulative release of (86.19±5.11)% until 48 h. In vitro cell experiments showed that HA-MCM-41-PTX had excellent targeting effect due to the modification of hyaluronic acid, which was easier to be uptaken by cells and exhibited great antitumor effect.CONCLUSION:
HA-MCM-41-PTX is an excellent drug delivery system with both controlled release and targeting antitumor effect.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2019
Type:
Article
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