Research Progress on Strategies of Overcoming Doxorubicin Resistance Based on Nanocarriers / 中国药学杂志

ABSTRACT

Multidrug resistance (MDR) refers to the cross-resistance of tumor cells to multiple chemotherapeutic drugs, which stems from long-term exposure to a certain chemotherapeutic drug. MDR is the most important defense mechanism for tumor cells and the main reason to failure of tumor chemotherapy. As a promising drug delivery system, nanocarriers can effectively overcome MDR by enhancing drug targeting to tumors, releasing drug selectively, increasing cellular uptake, the introduction of photochemical, and deliveing multiple active molecules synergistically. In this review, the progress on applications of nanocarriers in overcoming MDR are summarized.