Pharmacokinetics of Hydroxysafflor Yellow A Water-in-Oil Nanoemulsion / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 2108-2112, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-858121
ABSTRACT
OBJECTIVE:
To study the pharmacokinetics and bioequivalence of hydroxysafflor yellow A (HSYA) and hydroxysafflor yellow A nanoemulsion (HYAN) in rats.METHODS:
Twelve male rats were randomly divided into two groups. The rats were administered intragastrically with HSYA or HYAN, respectively, and then blood was collected from the venous plexus at different time points. HPLC method was used for the determination of HSYA blood concentration.RESULTS:
The main pharmacokinetic parameters of HYAN were as follows the area under curve (AUC0-24 h), peak concentration (ρmax), peak time (tmax) and clearance (CL) were (31.56±4.58) mg•L•h-1, (12.75±2.64) mg•L-1, (0.83±0.54) h and (1.89±0.93) L•h-1•kg-1, respectively. The AUC0-24 h, ρmax and tmax of HYAN increased by 5.49, 10.22 and 2.50 times, respectively, and the CL of HYAN was only 1/4 of that of HSYA. The 90% confidence intervals for AUC0-24 h and ρmax were not within the prescribed range of bioequivalence criteria.CONCLUSION:
Relative to HSYA, the high plasma concentration and prolonged peak time of HYAN in vivo can significantly improve the oral bioavailability of HSYA. HSYA solution and HYAN are not bioequivalent.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS