Application Research of Different Compression Model on Four Powder Excipients Compression / 中国药学杂志

ABSTRACT

OBJECTIVE: To conduct the contrastive studies of universal compression model to pharmaceutical powder compression characteristics effect base on Heckel and Kawakita equation founded.METHODS: The uniaxial compression tests were developed with three excipients of lactose, starch, microcrystalline cellulose and four mixture excipients of lactose, starch, microcrystalline cellulose with different mass fraction. The change rules between density and pressure and model error are analyzed of two different compression models respectively.RESULTS: The absolute density error value of Heckel and Kawakita compression model is within 4%, when the pressure is greater than 80 MPa,and the variance of Kawakita model is less than Heckel model.The absolute error value of Heckel and Kawakita compression model is within 3.73%, when the pressure is larger than 60 MPa, and the variance of Kawakita compression model less than Heckel model.CONCLUSION: During applying two universal compression models to analyze pharmaceutical powder compression characteristics, two models are suitable, when the pressure is between 80 and 240 MPa.