Research Progress in the Evaluation Methods of Microneedles Puncture Performance / 中国药学杂志

ABSTRACT

As a novel transdermal drug delivery technology,microneedles has some advantages including high efficiency and safety over other drug administration routes. The skin puncture performance is the premise and key for microneedles to deliver drugs. Based on the mechanical strength of the microneedles and the puncture effect of the skin, this review summarized the current evaluation methods of puncture performance. These methods were described here such as fracture strength measurement, pressure-displacement performance testing, organic dye staining, transepidermal water loss, electrical impedance method, histological sections, confocal microscopy and optical coherence tomography. The scope of application, advantages and disadvantages of various methods were analyzed, which provide references for other researchers to choose suitable evaluation method of microneedles puncture performance.