Chemical Constituents from Caulophyllum robustum (Ⅱ) / 中国药学杂志

ABSTRACT

OBJECTIVE: To isolate the chemical constituents from Caulophyllum robustum and confirm their chemical structures. METHODS: The chemical constituents were isolated by MCI gel, repeated silica gel chromatography, preparative liquid chromatography.and their structures were elucidated by NMR and MS etc. RESULTS: The structures of compounds 1-10 were identified as echinocystic acid (1), oleanolic acid-3-O-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranoside (2), hederagenin-3-O-β-D-glucopyranosyl-(1→3)-α-L-arabinopyranoside (3), hederagenin-3-O-β-D-glucopyranosyl-(1→2) [β-D-glucopyranosyl-(1→3)]-α-L-arabinopyranoside (4), 3-O-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranosyl echinocystic acid-28-O-α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester (5), 3-O-α-L-arabinopyranosyl hederagenin-28-O-(4-O-acetyl)-α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester (6), (6R, 7E, 9R)-9-hydroxy-4, 7-megastigmadien-3-one-9-O-β-D-glucoside (7), (9R)-9-hydroxy-4, 6-megastigmadien-3-one-9-O-β-D-glucoside (8), maltose (9), and sucrose (10). CONCLUSION: Compounds 1-10 are firstly isolated from the genus Caulophyllum except 5.