Synthesis and Antitumor Activity of Indole Podophyllotoxin Derivatives / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 862-868, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-858312
ABSTRACT
OBJECTIVE:
To synthesize 5-substituted indole-3-deoxypodophyllotoxin derivatives and study their antitumor activity.METHODS:
The target compounds were synthesized through a series of reactions and their anti-tumor activity in vitro were evaluated against Hela, K562 and K562/A02 cell lines by MTT as assay.RESULTS:
Ten target compounds were synthesized and confirmed by 1H-NMR, 13C-NMR, and HR-ESI-MS. All the target compounds had different degrees of cytotoxic activity in vitro. Most of the compounds had significant anti-MDR activity in vitro.CONCLUSION:
5-Substituted indole-3-deoxypodophyllotoxin derivatives have good antitumor activity and worth of further study.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2018
Type:
Article
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