Effect of Ginsenosides on the Pharmacokinetics of Etoposide in Rats / 中国药学杂志

ABSTRACT

OBJECTIVE: To investigate the pharmacokinetic interaction between ginsenosides and etoposide and provide useful information for clinical practice. METHODS: Eighteen male Wistar rats were randomly divided into three groups etoposide group(10 mgkg-1),the high dose ginsenoside group(etoposide 10 mgkg-1, ginsenoside 200 mgkg-1), the low dose ginsenoside group(etoposide 10 mgkg-1, ginsenoside 100 mgkg-1). Plasma samples were collected at different times after the drug administration from the orbital veins of the rats. An HPLC method was developed to determine the concentration of etoposide in rat plasma,and the pharmacokinetic parameters were calculated using DAS3.2.7. RESULTS: Compared with the etoposide group,AUC0-t and MRT0-t of the high dose ginsenoside group were increased by 46% and 24% respectively, and CL decreased by 19%, which was statistically significant difference. The AUC0-t of the low dose ginsenoside group had a significant increased(21%) compared with the etoposide group, while other pharmacokinetic parameters had no significant differences. CONCLUSION: Combination of ginsenosides and etoposide could significantly improve the plasma concentration and reduce excretion of etoposide.