Synthesis of Sacroflavonoside / 中国药学杂志

ABSTRACT

OBJECTIVE: To synthesize sacroflavonoside for laying foundation for the future study of its anti-tumor activity. METHODS: Sacroflavonoside was synthesized by nucleophilic addition, electrophilic substitution and dehydration cyclization reaction, and its structure was identified by NMR and MS. RESULTS: Sacroflavonoside was obtained by chemical synthesis and the yield was 53%. CONCLUSION: The synthesis process of sacroflavonoside is simple, the reaction condition is moderate, the raw material is easy to obtain and it is easy to prepare on a large scale.