Evaluation on Interventions for Chemotherapy Induced Thrombocytopenia / 中国药学杂志

ABSTRACT

OBJECTIVE: To compare the efficacy of different interventions on chemotherapy induced thrombocytopenia (CIT) in solid tumors. METHODS: Patients, registered at Fudan University Shanghai Cancer Center, who developed CIT (defined as platelet count 0.05). Recovery time were similar between interventions, most group had a median recovery time of 6 or 7 d. In grade III CIT, the recovery time of combination group is shorter than the other intervention groups (5.5 d in combination group vs 7 d in rhTPO group and rhIL-11 group), but there was no significant difference (P = 0.609, 0.605). In grade Ⅱ CIT, the recurrence rate was significantly higher in rhTPO group and rhIL-11 group than untreated group (35%, 38% vs 0%, P = 0.008, P = 0.006). In grade III CIT, the recurrence rate of rhTPO group was significantly higher than that of rhIL-11 group (55% vs 21%, P = 0.017). CONCLUSION: The result of the current study suggests that thrombopoietic agents are not recommended for patients with -Ⅱ CIT. For III - CIT, no significant differences are found in the efficacy between different interventions, thus rhIL-11 is recommended in consideration of cost.