Chemical Constituents from the Rhizome of Saururus chinensis / 中国药学杂志

ABSTRACT

OBJECTIVE: To study the chemical constituents from the rhizome of Saururus chinensis. METHODS: The chemical constituents from the rhizome of Saururus chinensis were extracted by supercritical CO2 extraction and isolated by various chromatographic methods, such as silica gel, MCI and pre-HPLC. Their structures were elucidated by physico-chemical constants and spectroscopic methods. RESULTS: Seventeen compounds were isolated and identified as aurantiamide acetate (1), echinuline (2), (-) -(7R, 8R) -7-O-acetylpolysphorin (3), elemicin (4), isoelemicin (5), 1, 4-bis (3, 4-dimethyoxyphenyl) -2, 3-dimethyl-1, 4-butanedione (6), saucerneol D (7), (2R) -3-(3', 4 ', 5'-trimethoxyphenyl) -1, 2 -propanediol (8), grandisin (9), rel-(7R, 8R, 7 'R, 8'R) -3', 4'- methylenedioxy-3, 4, 5, 5 '-tetramethoxy-7, 7 -epoxylignan(10), zanthopyranone (11), (±) -eritro-1-(3, 4, 5 -trimethoxy) -1, 2 -propanodiol (12), threo-3, 4, 5 -trimethoxy-7-hydroxy-1'-allyl-3', 5 '-dimethoxy-8. O. 4'-neolignan (13), (+) -(8R) -(2, 6 -dimethoxy-4-propenylphenoxy) -1-(3, 4, 5 -trimethoxyphenyl) propan-1-one (14), meso-dihydroguaiaretic acid(15), (-) -galbacin (16), and (-) - (7R, 8R) -7-O-acetylraphidecursinol B (17). CONCLUSION: Compound 6 is a new natural compound. Compounds 1 - 2, 4 - 6, 8 - 9 and 11 - 13 are isolated from this plant for the first time.