Recent Progress in Understanding the Mechanism of Neuroprotective Effect of Pinocembrin / 中国药学杂志

ABSTRACT

Pinocembrin (5, 7-dihydroxyflavanone), a flavanone, is a natural flavonoid compound extracted from honey, propolis, ginger roots, wild marjoram, and other plants. In preclinical studies, it has shown to have neuroprotective effects as well as the ability to reduce reactive oxygen species, protect the blood-brain barrier, modulate mitochondrial function, and regulate apoptosis. Considering these a variety of pharmacological activities, pinocembrin has potential as a drug to treat ischemic stroke and neurodegenerative disease. Its pharmacologic characteristics are summarized and mechanistic details relating preclinical studies are discusses.