Preparation of Aspirin Sustained Release Pellets Using Stearic Acid and Microcrystalline Cellulose / 中国药学杂志

ABSTRACT

OBJECTIVE: To evaluate microcrystalline cellulose(MCC) and stearic acid(SA) on extrusion-spheronisation(E-S) for aspirin sustained release pellets. METHODS: Mixtures with varying drug concentration and SA/MCC ratios were processed via non-aqueous E-S. Multi-index evaluation method were assessed by rheological behavious, drug stability and release in vitro compared with aqueous E-S. RESULTS: The extrusion was easier when SA/MCC was > 35%. When the ratio of SA/MCC was about 1, the roll effect was the best. The drug content was 65%. Compared with aqueous E-S, non-aqueous E-S was small and homogeneous pellets, better apparent characteristics, stability. There were no obvious different in drug release in vitro. CONCLUSION: These prove to be superior aids for water sensitive aspirin when exposed to non-aqueous solvent by E-S.