Research Progress of ABC Membrane Transporters and Their Regulation in Tumor Drug Resistance and New Mechanism of Detoxification / 中国药学杂志

ABSTRACT

Multidrug resistance of tumor cells is a material cause of chemotherapy failure, and the overexpression of adenosine triphosphate-binding cassette(ABC) membrane transporters is an important factor in multidrug resistance. Significant progress has been made in reversing multidrug resistance by reducing the expression of drug transporters on tumor cells; inspired by the mechanism of multidrug resistance, speeding up the efflux of poisons by increasing the expression of drug transporters is attracting more and more attention. In this review, We summarized the research progress on mechanism of membrane transp-orters in drug resistance in recent years, and new mechanism of detoxification based on these theories.