Preparation and Properties of Rifampicin-loaded Pluronic L61-PBSu Nanoparticles / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1924-1929, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-858528
ABSTRACT
OBJECTIVE:
To study the preparation of pluronic-modified biodegradable poly(butylene succinate) (PBSu) nanoparticles (NPs) and evaluate the release kinetics of the drug-loaded PBSu NPs and the cytotoxicity of the NPs, so as to provide a new platform for the application of biodegradable PBSu in drug delivery.METHODS:
Pluronic L61-modified PBSu NPs were prepared by emulsification method, and the morphology of the NPs was observed by transmission electron microscopy. The in vitro release kinetics of the rifampicin-loaded L61-PBSu NPs at 37 ℃ was studied. The cytotoxicity of the L61-PBSu NPs against human ovarian cancer cells (OVCAR-3) was evaluated by MTT assay.RESULTS:
The drug-loaded NPs had a unimodal distribution with an average size of (140±7) nm. The drug encapsulation efficiency attained 64.98%. The release time reached 27 h when the cumulative release percentage was 90%. The release kinetics followed non-Fickian mechanism. The NPs demonstrated very low cytotoxicity against OVCAR-3 cancer cells. Modification by L61 improved biocompatibility.CONCLUSION:
The Pluronic-modified PBSu NPs are easy to prepare, biocompatible, and show great promise as a new passive targeting platform for controlled release of insoluble drugs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2017
Type:
Article
Similar
MEDLINE
...
LILACS
LIS