Anti-Inflammatory Action and Mechanism on the Adjuvant Arthritis Mouse Model of Petroleum Ether Extract from Citrullus lanatus Vine / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1680-1684, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-858556
ABSTRACT
OBJECTIVE:
To study the pharmacological function of the petroleum ether extract from Citrullus lanatus vine (PEECLV) in treating adjuvant arthritis(AA) and explore the mechanism.METHODS:
AA in mice was made to observe the anti-inflammatory effect of PEECLV. Arthritis index was calculated by 5 grades evaluation. Thymus and spleen index were measured. The content of RF, PGE2, COX-1, COX-2 in serum were measured. The levels of TNF-α, IL-1β in serum were measured.RESULTS:
PEECLV can suppress the foot swelling degree in model mice. It can increase thymus index, reduce spleen index and AI of AA in mice. High-dose group can significantly reduce serum PGE2, IL-1β, COX-2 and COX-1 levels in AA in mice. All groups can reduce TNF-α and RF levels.CONCLUSION:
PEECLV has a certain degree therapeutic effect on AA, and the possible mechanism is to affect the production of inflammatory mediators and antioxidant.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2017
Type:
Article
Similar
MEDLINE
...
LILACS
LIS