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A New Iridoid glucoside from the Ripe Fruits of Cornus officinalis Sieb. et Zucc / 中国药学杂志
Chinese Pharmaceutical Journal ; (24): 1212-1216, 2017.
Article in Chinese | WPRIM | ID: wpr-858637
ABSTRACT

OBJECTIVE:

To study the chemical constituents from the ripe fruits of Cornus officinalis Sieb. et Zucc., and evaluate their protection on PC12 cells exposed to oxygen and glucose deprivation.

METHODS:

The compounds were isolated through various chromatographic methods including macroporous adsorption resin, silica gel, ODS, Sephadex LH-20 column chromatography, and preparative HPLC, and their structures were determined through spectroscopic analysis, including 1D and 2D NMR and MS data.

RESULTS:

Eight compounds were isolated from the water extract of the ripe fruits of Cornus officinalis Sieb. et Zucc., and their structures were elucidated as 6'-O-acetyl-7β-O-ethyl morroniside (1), chrysoderol(2), luteolin(3), 5-hydroxymethylfurfural(4), syringate(5),p-hydroxybenzoic acid(6), caffeic acid methyl ester(7), ethyl gallate(8).

CONCLUSION:

Compound 1 is a new iridoid glucoside, and compounds 2, 3, 5, 7 are obtained from Cornus officinalis for the first time. The MTT results show that compound 4 moderately increases the viability of OGD/R treated PC12 cells at the concentration of 1.0 μmol·L-1.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Pharmaceutical Journal Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Pharmaceutical Journal Year: 2017 Type: Article