Synthesis and Application of 2-Oxazoline Polymer in Drug Delivery Systems: A Review / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 713-720, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-858717
ABSTRACT
Poly(2-oxazoline)s (POx) have the same repeated C-C heteroatomic chains, which is very similar to polyethylene glycol (PEG), so POx have the similar properties to PEG, such as hydrophilicity and flexibility and low immunogenicity, etc. However, POx also possesses pH-sensitivity, thermo-responsibility, and does not interfere with the cellular uptake of nanocarriers, which highlights the potential of POx as an ideal alternative to PEG for constructing and modifying liposomes, micelles, polymer-drug conjugates and other nanocarriers. Among the POx, the chemical nature of poly(2-ethyl-2-oxazoline) (PEOZ) is the most active, which is the most widely used. In this paper, the synthesis of POx serial derivatives and their application in drug delivery systems were reviewed, mainly focused on PEOZ.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2017
Type:
Article
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