Research progress of nebulized heparin for acute lung injury / 中国药学杂志

ABSTRACT

It is widely recognized that alveolar fibrin deposition is a hallmark of acute lung injury. The inhaled anticoagulation regimens are employed to manage acute lung injury with the goal of improving lung function by decreasing airways fibrin deposition and obstruction. Inhalation administration may improve local biological availability and efficacy and lower the risk of systemic bleeding complications. Heparin is the most widely used anticoagulant in clinic. The author performed a systematic review of international preclinical studies and clinical trials of nebulized heparin for acute lung injury induced by smoke inhalation, severe infection and mechanical ventilation in animals and humans. It was demonstrated that nebulized heparin is a very prospective regimen in the treatment of acute lung injury.