The established of pediatric-focused adverse drug event triggers based on GTT by using delphi method / 中国药学杂志

ABSTRACT

OBJECTIVE: To establish pediatric-focused trigger of adverse drug event using Delphi expert consensus method, and provide a reference for clinical to develop ADE active monitoring based on GTT. METHODS: The formed trigger items were adopted to design an expert consultation questionnaire based on GTT white paper, related literatures and by expert pre investigation. Twenty-seven experts from Beijing, Shanghai and so on were chosen to do a two-round Delphi consultation. Trigger items were screened and modified. RESULTS: THE recovery rate of questionnaire were 92.6%, 100%. After two rounds of consultation the authority coefficient (Cr) was 0.81 ± 0.05. The coefficient of variation (CV) was 0.29 ± 0.13.The KendallW was 0.346, respectively(P < 0.001). Finally 36 trigger items were formulated, including 20 laboratory index, 9 antidotes, 4 clinical symptoms and 3 intervention measures. CONCLUSION: It is reasonable, feasible to adopt Delphi expert consensus method as pediatric-focused trigger of adverse drug events, which lays the foundation for the implementation of GTT.