Effects of different grinding methods on in vitro dissolution of ursodeoxycholic acid capsules / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 2037-2040, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-858893
ABSTRACT
OBJECTIVE:
To compare the in vitro dissolution of ursodeoxycholic acid capsules prepared by different grinding methods and screen the best grinding method.METHODS:
Using the large cup method, HPLC was used to investigate the similarity of dissolution behaviors between the reference preparation Ursofalk® (the original drug) and the self-made ursodeoxycholic acid capsules in four dissolution media. The grinding method which obtained product with qualified similarity factor f2 was determined as the best technology.RESULTS:
The ursodeoxycholic acid capsules made with raw material micronized by ball grinder for 3 min had similar dissolution curve to the original drug.CONCLUSION:
Rational preparation process is established for ursodeoxycholic acid capsules.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2016
Type:
Article
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