A preliminary study on the bone-targeting potential of a new type of bisphosphonate in rabbits / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1771-1775, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-858939
ABSTRACT
OBJECTIVE:
To study the bone-targeting potential and dynamic changing process in vivo of a new type of anti-osteoporosis bisphosphonate drug under research (SC).METHODS:
The distribution in rabbits and bone-targeting of SC was observed by isotope tracer technique. 99Tcm-SC was injected into the rabbits, then the SPECT images were collected and analyzed in 12 h.RESULTS:
The labeling rate of 99Tcm-SC could be maintained above 90% within 12 h, which proved the good stability of 99Tcm-SC in vitro. The rabbit bone imaging showed that the targeting of SC to bone was equivalent to MDP, a bone imaging agent.CONCLUSION:
This study provides valuable data for the non-clinical and clinical studies of SC. SC has a good potential for being developed into a new generation of anti-osteoporosis drug.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2016
Type:
Article
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