Protective effects of Sparstolonin B on mouse with intracerebral haemorrhage / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1572-1578, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-858971
ABSTRACT
OBJECTIVE:
To study the protective effects of sparstolonin B(8,5'-dihydroxy-4-phenyl-5,2'-oxidoisocoumarin, SsnB) on mouse with intracerebral haemorrhage (ICH).METHODS:
The effect of SsnB on neuronal cell death induced by Hb using a microglia-neuron transwell system was investigated. Autologous nonanticoagulated blood was collected from the tail artery of the mouse and then injected into the striatum using a syringe pump. Neurological deficit of the mouse with ICH was assessed 1,3,5 and 7 d after SsnB administration using modified neurological severity score system, and brain water content of the mouse cerebral tissues after ICH was measured at the same day. The concentrations of pro-inflammatory cytokines in perihematoma tissues, including interleukin-6, interleukin-1 p and tumor necrosis factor-α, were measured by ELISA assay.RESULTS:
The results show that SsnB significantly reduced the neurological deficit scores and the brain water content, and inhibited the levels of IL-6, IL-1β and TNF-α at first day and third day after ICH.CONCLUSION:
SsnB can improve the brain injury in mouse induced by ICH. The mechanism may involve increased the neuronal survival rate and decreased expression of pro-inflammatory cytokines of mouse after ICH.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2016
Type:
Article
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