Research progress of targeting Nrf2/ARE signaling pathway for the neuroprotective effect of sulforaphane / 中国药学杂志

ABSTRACT

Nrf2/ARE pathway has become an attractive target using phytochemicals for the prevention and treatment of oxidative stress-related diseases including neurodegenerative diseases, such as Alzheimer's disease (AD), and Parkinson's disease (PD). Among phytochemicals, sulforaphane (SFN) has demonstrated neuroprotective effects in several in vitro and in vivo studies. In particular, evidence suggests that beneficial effects of SFN could be mainly ascribed to its peculiar ability to activate the Nrf2/ARE pathway. Therefore, SFN appears to be a promising compound with neuroprotective properties that may play an important role in preventing neurode-generation. This contribution focuses on Nrf2/ARE-mediated signaling pathways, particularly in relation to neuroprotective effects of sulforaphane.