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Rapid identification of chemical constituents of folium hibisci mutabilis by UHPLC-Q-TOF-MS/MS / 中国药学杂志
Chinese Pharmaceutical Journal ; (24): 1162-1168, 2016.
Article in Chinese | WPRIM | ID: wpr-859032
ABSTRACT

OBJECTIVE:

To qualitatively analyze the chemical constituents of Folium hibisci Mutabilis by high performance liquid chromatography-electrospray ionization-quadrupole-time of flight-mass spectrometry (UHPLC-Q-TOF-MS/MS).

METHODS:

The separation was performed on a UHPLC Welch C18 column (2.1 mm×100 mm, 1.7 μm), with acetonitrile-0.1% formic acid as the mobile phase for gradient elution; ESI ion source was used; the data was collected in a negative ion mode. The chemical components of Folium hibisci Mutabilis were identified by analyzing the retention time, exact relative molecular mass, and cleavage fragments of MS/MS.

RESULTS:

A total of 73 compounds were identified in Folium hibisci Mutabilis, including 42 flavonoids, 15 triterpenoids, 11 organic acids, 3 coumarins, and 2 other kinds of compounds by UPLC-Q-TOF-MS.

CONCLUSION:

LC-MS/MS can identify the chemical components of Folium hibisci Mutabilis in a simple, which would provide a foundation for further exploration of the effective substances of Folium hibisci Mutabilis.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Diagnostic study Language: Chinese Journal: Chinese Pharmaceutical Journal Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Diagnostic study Language: Chinese Journal: Chinese Pharmaceutical Journal Year: 2016 Type: Article