An overview on the pathogenesis of sPLA2-IIA and related drug development / 中国药学杂志

ABSTRACT

Secretory phospholipase A2 group II A is an enzyme that hydrolyzes the sn-2 ester in glyceroacyl phospholipids present in lipoproteins and cell membranes. There have been an increasing number of reports regarding the pathogenesis of the enzyme in cardiovascular,tumor and autoimmune diseases in recent years and drug development targeting the enzyme is receiving more and more attention as a result. This article reviews research results in the above areas and current status of drug development based on reported sPLA2-II inhibitors.