Mechanisms of resistance to PBK-Akt-mTOR signaling pathway inhibitors / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 253-258, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-859199
ABSTRACT
The resistance to PBK-Akt-mTOR pathway inhibitors has close relationship to the negative feedback of its context-dependent signal pathways. According to our current understanding, the resistant mechanisms could be divided into the following basic conditions related to FOXO and hormone receptor, MYC-dependence, β-catenin-dependence, JAK/STAT pathway-dependence, MAPK pathway-dependence and related to AXL. The emergence of drug resistance to PBK-Akt-mTOR pathway inhibitors has greatly limited their curative effect. The reported resistance mechanisms to PBK-Akt-mTOR pathway inhibitors to search for potential strategies for overcoming resistance by drug combination were summarized.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2016
Type:
Article
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