Effect of CoQ10 on cortical bone in cyclophosphamide-treated rats / 中国药学杂志

ABSTRACT

OBJECTIVE: To investigate the preventive effects of coenzyme Q10 on cortical bone in cyclophosphamide-treated rats and compare CoQ10 with alendronate sodium. METHODS: Thirty-two three-month-old SPF and SD male rats were randomly divided into 4 groups (n=8 per group). Group 1 was treated with vehicle as the control group (CON group). Other groups were treated with cyclophosphamide (4.5 mg·kg-1·d-1) first, and then vehicle (CTX group), alendronate sodium (ALD 1 mg·kg-1·d-1) and CoQ10 (30 mg·kg-1·d-1) once a day for 15 d. At the experimental endpoint, The static and dynamic parameters of left tibia bone grinding by the bone histomorphometry and took the right femur bone biomechanical testing were observated. RESULTS: From bone histomorphometry parameters, cyclophosphamide can inhibit bone formation which make rat cortical bone thinning, bone marrow cavity to expand; reduced bone formation. Coenzyme Q10 can effectively promote bone formation, inhibit bone loss in rats by cyclophosphamide, the effect is better than the positive drug alendronate sodium. Compared with the CON group, biomechanical properties of maximal strength, break strength, break strain and toughness index were decreased significantly, while modulus of rigidity was increased significantly in the CTX group. Compared with the CTX group, the ALD group, only several parameters of the biomechanical properties were significantly improved. In contrast, in the CoQ10 group, the biomechanical properties were significantly improved. CONCLUSION: CoQ10 (30 mg·kg-1·d-1) on the microstructure of CTX rat tibia bone repair capacity better, and the ability to repair bone mass and reduce the risk of hip fracture is also superior ALD.