Research progress in protective mechanism of panax notoginsenosidum on cerebral ischemia-reperfusion injury / 中国药学杂志

ABSTRACT

Panax notoginsenosidum(PNS), which was proved to have the efficacy of increasing cerebral blood flow,improving microcirculation and anti-platelet aggregation, has been widely used for the treatment of cerebral ischemia-reperfusion injury(CIRI). A line of current studies have shown that the protective mechanism of PNS on CIRI is associated with multiple ways, including the roles of PNS on free radicals and lipid peroxides, apoptosis, calcium channels, neuronal damage, and the protein expression of signaling pathways etc. The above protective mechanisms underlying the role of PNS on CIRI provide well-founded scientific evidences for the exploitation and application of PNS. In this paper, the progress in protective mechanism of PNS on CIRI by summarizing and analyzing data collected from literatures published in recent years is reviewed.