Research progress of targeting HO-1/NOX2 pathway for the treatment of Parkinson's disease / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 2024-2027, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-859278
ABSTRACT
Accumulating evidence strongly supports the involvement of oxidative stress in the etiology of Parkinson's disease (PD). ROS derived from the NOX2-containing NADPH oxidase play important role in the pathogenesis of PD. Our intent was to review the research history about the role of NOX2-containing NADPH oxidase in PD. Neuroprotective effect of heme oxygenase-1 (HO-1) in protecting neurons against PD-related neurotoxin-induced oxidative stress dependant injury, and a major emphasis has been on the relationship between HO-1 and NOX2-containing NADPH oxidase. Specific activation of HO-1 gene expression by pharmacological modulation may represent a novel target for therapeutic treatment of PD through inhibiting NOX/ROS. A new target for PD therapy through inhibiting NOX/ROS, thereby modulating HO-1/NOX2 axis is highlighted.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2015
Type:
Article
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