Preparation and characterization of terminal modified hyaluronic acid copolymer micelles / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1973-1978, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-859298
ABSTRACT
OBJECTIVE:
To synthesize hyaluronic acid-octadecene (HOY) copolymers by terminal thiolation modification of hyaluronic acid (HA), prepare doxorubicin-loaded micelles and investigate its pharmaceutical characteristics.METHODS:
HOY copolymers were synthesized through Michael addition reaction. The doxorubicin-loaded copolymer micelles were prepared with ultrasonic method, then the particle size, Zeta potential, encapsulation efficiency, drug loading efficiency and in vitro release behavior were studied.RESULTS:
HOY copolymers were synthesized successfully. The particle size and Zeta potential of the drug-loaded micelles were (237.2±2.7) nm and (-22.37±0.38) mV, and the encapsulation efficiency and drug loading rate were (89.8±0.011)% and (5.4±0.007)%, respectively. Moreover, the accumulative release of doxorubicin in vitro was about 70% in 48 h, indicating that the drug was released slowly from the micelles.CONCLUSION:
This study develops a new micellar system based on terminal modified HA, and provides a reference for the study of HA nanocarrier.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2015
Type:
Article
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