Identification of the primary impurity in ebastine and its souce analysis / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1992-1995, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-859302
ABSTRACT
OBJECTIVE:
To identify the structure of the primary unknown impurity of ebastine, thus offer technological support for reducing the impurity content and improving the quality of product.METHODS:
The primary unknown impurity was separated and extracted from ebastine by preparative HPLC. The structure of the primary unknown impurity was analyzed by EI-MS, NMR, IR and UV and further confirmed with commercial reagent.RESULTS:
The primary unknown impurity was elucidated as benzene, 1,1,2,2-tetra-phenyle thane, which is the by-product of ebasline synthesis.CONCLUSION:
This study provides reference for the improvement of quality control and process optimization of ebastine.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2015
Type:
Article
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