Change of cytochrome P450 2C in the process of development and its clinical significance / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1843-1848, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-859307
ABSTRACT
This paper presents a review of the change of cytochrome P450 2C (CYP2C) in human development process and the effect of its gene polymorphism on clinical medication. The relevant literature at home and abroad was reviewed, analyzed, and summarized. The expression and activity of CYP2C9 and CYP2C19 enzymes are different at different ages, which has a direct effect on clinical drug use in pediatric patients. It has vital significance to further research the change rules of CYP2C9 and CYP2C19 and the influence of gene polymorphism on drug metabolism in the process of development for improving the efficacy and rationality of pediatric medication.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2015
Type:
Article
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