Metabolites of endophytic fungus Xylaria sp. with biological activities / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1853-1856, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-859309
ABSTRACT
OB JECTIVE To investigate the chemical constituents from the fermented rice substrate of endophytic fungus Xylaria sp. HCCB03890. METHODS:
The compounds were isolated with silica gel column chromatography and reversed-phase high performance liquid chromatography. The structures of these compounds were elucidated through MS and NMR spectroscopic analysis. The anti-microbes activities were evaluated by disk diffusion method, cytotoxic activities were determined by MTT method, and anti-HIV activities were measured by using a firefly luciferase assay system.RESULTS:
Six compounds were isolated and identified as TV-acetyltyra-mine(1), schizostatin(2), piliformic acid(3), stigmast-5,22-dien-3-ol(4), dankasterone(5) and demethylincisterol(6) on the basis of spectroscopic data analyses. Compound 3 showed moderate anti-microbial activity. Compounds 4-6 exhibited cytotoxic and anti-HIV activities, especially, and compund 5 and 6 showed significant anti-HIV activities with IC50 values of 0.4 and 0.9 μg · mL, respectively.CONCLUSION:
Compounds 2, 5 and 6 were for the first time isolated from Xylaria sp., moreover, 5 and 6 are for the first time found in terrestrial microbes.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2015
Type:
Article
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