Preparation of Lutein Thermosensitive in situ gels for ophthalmic use and the in vitro release / 中国药学杂志
Chinese Pharmaceutical Journal
; (24): 1880-1884, 2015.
Article
in Zh
| WPRIM
| ID: wpr-859314
Responsible library:
WPRO
ABSTRACT
OBJECTIVE: To optimize the formulation of the lutein thermosensitive in situ gels by using central composite design-response surface methodology, and study the drug release in vitro. METHODS: Gelation temperature was served as the indicator. The influences of the amounts of Poloxamer 407 and Poloxamer 188 on the gelation temperature were investigated. Central composite design-response surface method was used to optimize the prescription. The drug release profile of the preparation was investigated with a membrane-less dissolution model. RESULTS: The amounts of Poloxamer 407 and Poloxamer 188 had quantitative relationships with the gelation temperature. The optimum prescription was as follows: the mass concentration of P407 was 0.21 g · mL-1, and the mass concentration of P188 was 0.03 g · mL-1. The dissolution and drug release of the gels followed zero-order kinetics equation. CONCLUSION: Central composite design-response surface methodology can be applied to optimize the formulation of the lutein thermosensitive in situ gels.
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Pharmaceutical Journal
Year:
2015
Type:
Article